Repeat COVID vaccines provoke two kinds of inferior antibodies, study finds

As the Trump administration winds down the National Institutes of Health's devotion to increasing COVID-19 vaccine uptake, expanding mRNA technology and policing purported wrongthink, its incoming director – dubbed a "fringe epidemiologist" by a predecessor – will have no shortage of supportive research to call upon.

Spanish scientists documented a second so-called class switch in people with "repeated" mRNA COVID jabs, meaning their bodies start churning out two kinds of antibodies that learn to live with infection rather than destroy it, not just the IgG4 antibodies observed in prior studies.

"IgG4 is primarily involved in regulatory functions, and is associated with immune tolerance and chronic antigen exposure," while IgG2 targets "polysaccharide antigens" and "has received less attention" in the context of weakening immune response to COVID, they wrote this month in the British Infection Association's Journal of Infection.

"Here, we show that higher levels of IgG4 and IgG2, as well as higher proportions of non-cytophilic [nonbinding] to cytophilic antibodies, following booster vaccination, are associated with a heightened risk of SARS-CoV-2 breakthrough infection."

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